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Donor eggs
In what cases are donor eggs used?
One of the most important factors influencing the effectiveness of IVF treatment is the quality of the eggs, which, in turn, is largely determined by the age of the woman from whom the eggs were obtained. All the eggs that will be in a woman's body throughout her life are laid in the first weeks of her intrauterine development. With the onset of puberty, cells are consumed in each menstrual cycle until their supply is depleted and the ovaries cease to function.
In addition, as a woman's age increases, the number of eggs with various chromosomal abnormalities increases. A common type of chromosomal pathology is Down syndrome, which is most common if a woman becomes pregnant over the age of 38. Decreased fertility with age is a natural process, and currently there is no way to "rejuvenate" the ovaries, so the effectiveness of infertility treatment in women over 35 years of age is significantly reduced. The use of eggs obtained from young female donors significantly increases the effectiveness of treatment due to the good quality of their eggs. Donor eggs are used to achieve pregnancy in women with various reproductive problems, including premature ovarian depletion, decreased ovarian reserve, poor egg quality in previous IVF cycles, as well as in women with chromosomal translocations or genetic diseases to avoid their transmission to offspring.
The first pregnancy using donor eggs was obtained in 1984. Since then, more than 50,000 children have been born in the United States alone after using this method.
The first pregnancy using donor eggs was obtained in 1984. Since then, more than 50,000 children have been born in the United States alone after using this method.
Egg donors can be:
- relatives and acquaintances of patients,
- anonymous professional donors.
Information about the identity of the anonymous donor is confidential, and she does not receive information about the patients for whom her eggs are intended. After choosing a donor, she undergoes a medical and genetic examination, during which it is determined whether she meets all the necessary requirements for an egg donor. The donor signs an informed consent stating that her eggs and the embryos obtained from them will be the property of the patients. After completing the examination and signing the legal documents, the treatment cycle can be started.
Requirements for professional donors at the VitroMed Center:
- physical and mental health,
- age from 20 to 30 years inclusive,
- the presence of their own healthy child,
- the absence of abnormalities in appearance (correct physique and facial features).
- Synchronization of the menstrual cycles of the donor and recipient using gonadotropin-releasing hormone agonists (diferelin, decapeptil, buserelin) or oral contraceptives.
- Stimulation of ovulation of the oocyte donor using gonadotropins (menopur, puregone, gonal-F).
- Administration of an ovulatory dose of chorionic gonadotropin to a donor
- Preparation of the endometrium of the recipient with estradiol and progesterone preparations (proginova, utrozhestan).
- Puncture of the donor's ovaries, fertilization of the obtained eggs with the sperm of the husband (donor) and embryo transfer to the patient.
The Egg Donation program includes the following stages:
The egg donor undergoes a standard cycle of in vitro fertilization (IVF), while the patient takes estradiol and progesterone preparations to prepare the uterine endometrium for implantation. The donor's ovaries are stimulated to produce several eggs, the eggs are extracted by transvaginal puncture, fertilized with the sperm of the patient's husband and cultured in the laboratory. After three to five days of cultivation, two embryos of the best quality are transferred to the patient's uterus.
Indications for IVF using donor eggs:
- The absence of eggs due to natural menopause, premature ovarian wasting syndrome, a condition after ovarian removal, radio or chemotherapy, as well as developmental abnormalities.
- Functional egg inferiority in women with genetic disorders that can be transmitted to their offspring.
- The ineffectiveness of several previous attempts of standard IVF and PE with insufficient ovarian response to ovulation stimulation, repeated receipt of low-quality embryos, the transfer of which does not lead to pregnancy.
Contraindications:
- Somatic and mental illnesses in which there are contraindications for carrying a pregnancy;
- Congenital malformations or acquired deformities of the uterine cavity, in which it is impossible to implant embryos;
- Ovarian tumors;
- Hyperplastic processes of the endometrium;
- Benign uterine tumors requiring surgical treatment;
- Acute inflammatory diseases of any localization;
- Malignant neoplasms of any localization, including in the anamnesis.
The presence of severe male infertility factor does not exclude the use of donor eggs. Aspiration of spermatozoa from the epididymis (PESA, MESA, TESA) and injection of a single sperm into the cytoplasm of an egg (ICSI) are two new methods of treating male infertility that can be used in combination with the use of donor eggs. Donor eggs can also be used in combination with the use of donor sperm.
In the past, married couples with serious egg or sperm abnormalities had only two choices: adoption or childlessness. Today, egg donation, TESA, and ICSI provide a third option: an opportunity for a married couple to experience pregnancy and childbirth together.
Egg donors are at a certain risk of complications and difficulties associated with the need to combine work with the donation cycle, so they receive appropriate financial compensation for their participation in the donation program.
The use of donor eggs is an expensive method of treatment, as the selection, examination of donors and their financial compensation increase the cost of IVF procedures. However, the high performance of in vitro fertilization (IVF) programs with donor eggs gives many couples the highest chance of success.
Egg donors are at a certain risk of complications and difficulties associated with the need to combine work with the donation cycle, so they receive appropriate financial compensation for their participation in the donation program.
The use of donor eggs is an expensive method of treatment, as the selection, examination of donors and their financial compensation increase the cost of IVF procedures. However, the high performance of in vitro fertilization (IVF) programs with donor eggs gives many couples the highest chance of success.
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Address: 10/2 Hayasi str., Yerevan, 0082, Republic of Armenia
Tel.: +374 98-976-595
Email: vitromedsurrogacyclinic@gmail.com
Tel.: +374 98-976-595
Email: vitromedsurrogacyclinic@gmail.com
